Atletico Madrid have the chance to extend their unbeaten run to start their league campaign to six games when they welcome Deportivo la Coruna to the Vicente Calderon on Sunday afternoon at 15.15 GMT.
Following quite a taxing game last Wednesday against Barcelona and an utterly important game this coming Wednesday against Bayern Munich in the Champions League, Simeone´s ´partido a partido´ philosophy will be tested to the limit.
The big question is whether he risks taking his eye off the ball and underestimating Depor in an effort to keep his best players fresh on Sunday.
Some of the players brought in over the summer were brought in for reasons such as this and Simeone has said as much in the build up to the game.
``From here to Wednesday many things can happen. The intention is to go out onto the pitch with those players who we think can resolve the game and do best.''
He added: ``The squad is younger than other seasons, (Nicolas) Gaitan and (Kevin) Gameiro have given us experience but we have a very good squad and that strengthens the team.''
Atletico still have Miguel Angel Moya (knee) out injured along with Tiago (hamstring) and Alessio Cerci (not being very good at training) but otherwise have a full bill of health and no suspensions.
Depor´s goalkeeper German Lux was full of the typical talk you hear before a game with Atletico, "They are difficult to beat, but not impossible. They are very hard working and know what they want to do."
Having lost Lucas Perez during the summer transfer window, Deportivo have struggled massively with scoring goals. They have only landed one, in a recent 2-1 loss to Leganes, in the last four games. Those games consist of two draws and two losses.
It is highly doubtful that Depor topple Atletico but the same was said when Luis Enrique shuffled almost his entire deck before the Alaves game...and look what happened there. Que bonito!