Atletico are faced with a dilemma on Wednesday night. Does Diego Simeone send them out to capitalise on Barca's recent misfortune or hold something back in an effort to pinpoint their weak points and attack in due time.
The general consensus is that there is a sense of anxiety surrounding Barcelona, Simeone knows this and the opening half an hour could be as intense as anything we have seen at the Vicente Calderon this season.
Fernando Torres is suspended for the game for his sending off against Barcelona last Tuesday and so Griezmann looks to be ready to lead the line against a relatively shaky Barcelona back four. It was suggested that Luciano Vietto might start up front but given his form since joining the club it is doubtful that Simeone will risk him in the biggest game of Atletico's season.
Saul was rested during Atletico's victory over Espanyol and will be expected to put in a massive shift in midfield if the hosts are to overwhelm Barcelona in search of that first goal.
It is highly doubtful that Luis Enrique will spring too many surprises at the Vicente Calderon. Suarez is set to return to action having been replaced Munir at the weekend. An injury to Rafinha and an uninspiring start to life at Barcelona will ensure that Andres Iniesta and Ivan Rakitic will also regain their roles having also been rested for the trip to the Anoeta on Saturday.
Ter Stegen retains his Champions League place while Jordi Alba looks likely to slot in at left back in place of Sergi Roberto, who started against Real Sociedad.